Skin, Anti-Aging & Longevity, Prescription Skincare

Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g — Complete Product Information & Specifications

Custom-compounded prescription facial cream combining bioidentical Estriol (0.3%), Tretinoin (0.025%), Niacinamide (4%), and Hyaluronic Acid to restore dermal collagen, elasticity, and barrier hydration.

Product overview

During perimenopause, menopause, and chronological aging, declining dermal estrogen signaling leads to a rapid loss of Type I and Type III collagen—up to 30% within the first five years of menopause—resulting in skin thinning, crepiness, fine lines, and moisture depletion. Our Rx Anti-Aging Night Cream combines bioidentical Estriol (0.3%), a gentle topical estrogen receptor-beta (ER-β) agonist that stimulates dermal fibroblasts locally without significant systemic hormone absorption, with gold-standard Tretinoin (0.025%).

To ensure exceptional skin barrier tolerance and luminosity, the formula integrates Niacinamide (4%) to stimulate ceramide synthesis and calm retinoid-induced erythema, alongside Hyaluronic Acid (1%) for deep epidermal hydration. Dispensed in a light-proof metered airless pump, each nightly application visibly firms skin texture, softens wrinkles, and restores youthful bounce.

Through Join Amble Health, patients complete a streamlined online medical intake reviewed by a licensed healthcare provider. When clinically appropriate, your prescription or wellness protocol is fulfilled by a vetted partner pharmacy and shipped directly to your door with clear administration instructions, dosing schedules, and ongoing clinical support.

Product specifications

Product Name	Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g
SKU	AMB-SKIN-ESTRIOL-TRET
Category	Skin, Anti-Aging & Longevity, Prescription Skincare
Active Ingredients & Strength	Estriol USP 0.3% + Tretinoin USP 0.025% + Niacinamide 4% + Sodium Hyaluronate 1%
Dosage Form & Schedule	Metered Airless Dermatological Pump Dispenser (30 g) — Apply 1 metered pearl-sized pump to clean, dry facial skin in the evening (start 3 nights/week, increasing to nightly as tolerated); apply SPF 30+ daily
Price	$79.00
Availability	In stock (Provider Evaluation Required)

Product features

Quadruple-active dermatological synergy: Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid 1%.
Targets estrogen-deficient dermal thinning, collagen loss, fine lines, and uneven pigmentation.
Airless metered pump protects retinoid and bioidentical hormone potency from air and light degradation.
Structured specification table and transparent monthly program pricing with no hidden membership fees.
Direct pharmacy fulfillment with lot traceability, patient administration guides, and provider messaging access.

Quality and documentation

Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g is a clinician-guided prescription or specialty wellness formulation prepared by licensed U.S. 503A and 503B compounding pharmacies utilizing USP-grade active pharmaceutical ingredients. Compounded medications are customized to individual patient dosing or delivery needs and are not FDA-approved finished drug products; every batch undergoes potency, sterility, and endotoxin verification where applicable.

Every order is accompanied by pharmacy-issued labeling detailing the active ingredient concentrations, beyond-use date (BUD) or manufacturer expiration date, lot number, and step-by-step patient administration instructions. Patients should verify the package seal and storage instructions immediately upon delivery.

Storage and handling

Store at controlled room temperature (68°F–77°F) away from direct heat and sunlight.

Always keep medications and bioactive peptides out of reach of children and pets. Do not use any product past the printed expiration or beyond-use date on the pharmacy label, and never share prescription medications with another person.

Important product information

Product descriptions on Join Amble Health are provided for educational and catalog transparency purposes and do not replace individualized medical advice, diagnosis, or treatment from a licensed clinician. Eligibility for prescription weight management, hormone optimization, peptide therapy, or dermatological treatment is determined solely by your evaluating healthcare provider based on your medical history, current medications, contraindications, and laboratory findings where required.

Price, delivery and purchase terms

Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g is listed at $79.00 in the Amble Health Shop under Skin, Anti-Aging & Longevity, Prescription Skincare. Temperature-sensitive injectable and biological formulations are shipped via expedited insulated cold-chain carrier, while room-temperature oral, sublingual, nasal, and topical formulations ship in discreet protective packaging with full tracking.

Frequently asked questions

What is included with Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g?

Each 4-week supply of Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g (AMB-SKIN-ESTRIOL-TRET) includes the prescribed formulation (Estriol USP 0.3% + Tretinoin USP 0.025% + Niacinamide 4% + Sodium Hyaluronate 1% in Metered Airless Dermatological Pump Dispenser (30 g) format), complete pharmacy labeling, administration supplies if applicable, and ongoing asynchronous clinical support through your Amble patient portal.

How is Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g administered?

Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g is formulated as a Metered Airless Dermatological Pump Dispenser (30 g) and is typically used according to the following schedule: Apply 1 metered pearl-sized pump to clean, dry facial skin in the evening (start 3 nights/week, increasing to nightly as tolerated); apply SPF 30+ daily. Your prescribing clinician will provide personalized dosing and titration instructions tailored to your clinical goals and tolerance.

Do I need a prescription or medical consultation for Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g?

Yes. After selecting your treatment plan, you will complete a comprehensive online health intake. A licensed healthcare provider in your state reviews your medical history, contraindications, and treatment goals before issuing a prescription to our partner pharmacy.

How should I store Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g once it arrives?

Store at controlled room temperature (68°F–77°F) away from direct heat and sunlight. Always inspect the pharmacy label upon arrival and follow the specific storage temperature and light-protection guidelines printed on your container.

Can Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g be combined with other Amble Health protocols?

Many patients pair metabolic, longevity, or dermatological protocols under clinician supervision—such as combining GLP-1 therapy with NAD+ cellular support or gastro-protective B6/B12 co-factors. Disclose all current medications and supplements during intake so your provider can verify compatibility.

Where can I review pricing and shipping updates?

Current pricing ($79.00), stock status, and delivery terms are displayed directly on this product page and in your checkout summary prior to order confirmation.

Product and regulatory references

US online ordering information

Information for customers reviewing Estriol + Tretinoin + Niacinamide Cream, 30g online from the United States.

A catalog listing or an enabled Add to cart button is not clinical approval or confirmation of lawful dispensing. Before ordering, confirm the exact formulation, strength, quantity, required prescription review, dispensing pharmacy and eligibility in your state. No nationwide prescribing or fulfillment coverage is implied.

Use the live price and stock display on this page and review the final checkout total. Delivery, tax and return conditions depend on the product and destination; do not assume a delivery date or eligibility from this page alone.

For product or ordering questions, email hello@joinamblehealth.com. Read the Amble terms of service or visit your Amble account.

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Rx Anti-Aging Night Cream (Estriol 0.3% + Tretinoin 0.025% + Niacinamide 4% + Hyaluronic Acid) — 30g