Weight Loss, Anti-Aging & Longevity, Wellness

Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply — Complete Product Information & Specifications

Extended-Release Metformin HCl (500 mg–1,000 mg) AMPK cellular longevity activator for insulin sensitivity, glycemic stability, and post-GLP-1 weight maintenance.

Product overview

Metformin HCl Extended-Release (ER) is a foundational metabolic and cellular longevity therapy studied extensively in the landmark TAME (Targeting Aging with Metformin) framework. By activating AMP-activated protein kinase (AMPK)—the body’s master cellular energy sensor—Metformin reduces hepatic gluconeogenesis, enhances peripheral insulin sensitivity, and promotes healthy mitochondrial autophagy.

Unlike immediate-release metformin, the Extended-Release (ER) hydrophilic matrix releases the active compound gradually along the gastrointestinal tract, dramatically improving digestive comfort. Clinicians prescribe Metformin ER for standalone metabolic health, PCOS support, longevity optimization, and as a cornerstone off-ramp maintenance therapy to prevent weight regain after GLP-1 treatment.

Through Join Amble Health, patients complete a streamlined online medical intake reviewed by a licensed healthcare provider. When clinically appropriate, your prescription or wellness protocol is fulfilled by a vetted partner pharmacy and shipped directly to your door with clear administration instructions, dosing schedules, and ongoing clinical support.

Product specifications

Product Name	Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply
SKU	AMB-METFORMIN-ER
Category	Weight Loss, Anti-Aging & Longevity, Wellness
Active Ingredients & Strength	Metformin Hydrochloride Extended-Release USP (500 mg per tablet, 30 or 60 tablets)
Dosage Form & Schedule	Extended-Release (ER) Oral Tablets — Take 1 to 2 tablets (500 mg–1,000 mg) once daily with your evening meal
Price	$25.00
Availability	In stock (Provider Evaluation Required)

Product features

Extended-Release (ER) formulation engineered for superior gastrointestinal comfort and once-daily evening dosing.
Activates AMPK cellular longevity pathways, improves insulin sensitivity, and blunts post-meal glucose spikes.
Gold-standard metabolic maintenance option for patients transitioning off injectable GLP-1 therapy.
Structured specification table and transparent monthly program pricing with no hidden membership fees.
Direct pharmacy fulfillment with lot traceability, patient administration guides, and provider messaging access.

Quality and documentation

Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply is a clinician-guided prescription or specialty wellness formulation prepared by licensed U.S. 503A and 503B compounding pharmacies utilizing USP-grade active pharmaceutical ingredients. Compounded medications are customized to individual patient dosing or delivery needs and are not FDA-approved finished drug products; every batch undergoes potency, sterility, and endotoxin verification where applicable.

Every order is accompanied by pharmacy-issued labeling detailing the active ingredient concentrations, beyond-use date (BUD) or manufacturer expiration date, lot number, and step-by-step patient administration instructions. Patients should verify the package seal and storage instructions immediately upon delivery.

Storage and handling

Store at controlled room temperature 68°F to 77°F (20°C to 25°C) away from light and moisture.

Always keep medications and bioactive peptides out of reach of children and pets. Do not use any product past the printed expiration or beyond-use date on the pharmacy label, and never share prescription medications with another person.

Important product information

Product descriptions on Join Amble Health are provided for educational and catalog transparency purposes and do not replace individualized medical advice, diagnosis, or treatment from a licensed clinician. Eligibility for prescription weight management, hormone optimization, peptide therapy, or dermatological treatment is determined solely by your evaluating healthcare provider based on your medical history, current medications, contraindications, and laboratory findings where required.

Price, delivery and purchase terms

Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply is listed at $25.00 in the Amble Health Shop under Weight Loss, Anti-Aging & Longevity, Wellness. Temperature-sensitive injectable and biological formulations are shipped via expedited insulated cold-chain carrier, while room-temperature oral, sublingual, nasal, and topical formulations ship in discreet protective packaging with full tracking.

Frequently asked questions

What is included with Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply?

Each 4-week supply of Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply (AMB-METFORMIN-ER) includes the prescribed formulation (Metformin Hydrochloride Extended-Release USP (500 mg per tablet, 30 or 60 tablets) in Extended-Release (ER) Oral Tablets format), complete pharmacy labeling, administration supplies if applicable, and ongoing asynchronous clinical support through your Amble patient portal.

How is Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply administered?

Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply is formulated as a Extended-Release (ER) Oral Tablets and is typically used according to the following schedule: Take 1 to 2 tablets (500 mg–1,000 mg) once daily with your evening meal. Your prescribing clinician will provide personalized dosing and titration instructions tailored to your clinical goals and tolerance.

Do I need a prescription or medical consultation for Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply?

Yes. After selecting your treatment plan, you will complete a comprehensive online health intake. A licensed healthcare provider in your state reviews your medical history, contraindications, and treatment goals before issuing a prescription to our partner pharmacy.

How should I store Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply once it arrives?

Store at controlled room temperature 68°F to 77°F (20°C to 25°C) away from light and moisture. Always inspect the pharmacy label upon arrival and follow the specific storage temperature and light-protection guidelines printed on your container.

Can Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply be combined with other Amble Health protocols?

Many patients pair metabolic, longevity, or dermatological protocols under clinician supervision—such as combining GLP-1 therapy with NAD+ cellular support or gastro-protective B6/B12 co-factors. Disclose all current medications and supplements during intake so your provider can verify compatibility.

Where can I review pricing and shipping updates?

Current pricing ($25.00), stock status, and delivery terms are displayed directly on this product page and in your checkout summary prior to order confirmation.

Product and regulatory references

US online ordering information

Information for customers reviewing Metformin Extended-Release Listing online from the United States.

A catalog listing or an enabled Add to cart button is not clinical approval or confirmation of lawful dispensing. Before ordering, confirm the exact formulation, strength, quantity, required prescription review, dispensing pharmacy and eligibility in your state. No nationwide prescribing or fulfillment coverage is implied.

Use the live price and stock display on this page and review the final checkout total. Delivery, tax and return conditions depend on the product and destination; do not assume a delivery date or eligibility from this page alone.

For product or ordering questions, email hello@joinamblehealth.com. Read the Amble terms of service or visit your Amble account.

Insulin Sensitivity

Metformin HCl Extended-Release (ER 500mg – 1000mg) Longevity & Glycemic Protocol — 30-Day Supply