How to Use the New Wegovy 7.2mg Single-Dose Pre-Filled Pen: 8-Step Guide

Key Takeaways

Each monthly carton contains 4 single-use 7.2mg auto-injector pens with built-in hidden needles — replacing three separate 2.4mg FlexTouch injections and 12 needles per month.
Press firmly flat against abdomen, thigh, or upper arm until the yellow bar stops moving and you hear a second click (5–10 seconds); the safety shield locks automatically.
Store refrigerated (2–8°C), or below 30°C for up to 28 days (vs. 6 weeks for FlexTouch pens); missed doses can be taken within 5 days.

In the Phase 3b STEP UP trial, stepping up from 2.4mg to 7.2mg weekly semaglutide helped adults with obesity reach ~19%–20.7% average weight loss (3). Previously, taking 7.2mg required administering three separate 2.4mg FlexTouch injections every week — now replaced by Novo Nordisk’s single-dose 7.2mg pre-filled auto-injector pen (1,2).

8-step injection checklist for the 7.2mg single-dose pen

Verify the label reads Wegovy 7.2mg and check the expiration date (especially if you still have older FlexTouch pens in the fridge).
Inspect the viewing window: liquid must be clear, colorless, and particle-free.
Select & rotate your site: abdomen, front of thigh, or upper arm.
Pull off the cap straight: the needle is built in and stays hidden — nothing to screw on.
Press firmly flat against skin to start injection (watch the yellow indicator bar move and listen for the first click).
Keep holding firmly for 5–10 seconds until the yellow bar stops moving and you hear the second click — lifting early delivers an incomplete dose.
Lift straight off skin: the hidden needle guard locks automatically.
Place the entire single-use pen into a sharps container (never household trash).

Storage & missed-dose rules

Cold-chain & travel: Store unopened pens at 2°C–8°C in the fridge; if needed for travel, a 7.2mg single-dose pen may stay unrefrigerated below 30°C for up to 28 days (shorter than the 42-day / 6-week allowance on 2.4mg FlexTouch pens) (1,4).
Missed dose: Take as soon as remembered if within 5 days of your scheduled day; if more than 5 days have passed, skip and resume on your normal weekly schedule (never double-dose).

Questions about GLP-1 dosing? Connect with a clinician via our online consultation.

References

Novo Nordisk. Wegovy (semaglutide) 7.2 mg single-dose pen — U.S. prescribing information. 2026.
Novo Nordisk. Wegovy Pen Guide and Dosing Instructions. 2026.
Wharton S, et al. Once-weekly semaglutide 7.2 mg in adults with obesity (STEP UP)00226-8/abstract). Lancet Diabetes Endocrinol. 2025.

Medical Editorial Review: Reviewed by the Amble Clinical Editorial Team. This article is for educational purposes only and does not replace an individualized consultation with a licensed healthcare professional.