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- Mounjaro always starts at 2.5mg once weekly for Weeks 1–4 so your digestive tract adapts with minimal nausea, constipation, or diarrhea.
- Doses step up in 2.5mg increments at least 4 weeks apart (2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg).
- Licensed maintenance strengths are 5mg, 10mg, and 15mg — many patients achieve sustainable weight loss without ever needing the maximum 15mg pen.
When starting Mounjaro (tirzepatide) for weight management, everyone begins at the 2.5mg once-weekly starter dose — never jumping straight into higher strengths, even if you want fast results.
Standard 4-week Mounjaro titration pathway
| Treatment Weeks | Weekly Injection Strength | Clinical Role |
|---|---|---|
| Weeks 1–4 | 2.5mg | Introductory gut-adaptation starter dose (not a maintenance dose) |
| Weeks 5–8 | 5mg | First therapeutic & licensed maintenance strength |
| Weeks 9–12 | 7.5mg | Step-up bridge dose (if needed) |
| Weeks 13–16 | 10mg | Mid-tier licensed maintenance strength |
| Weeks 17–20 | 12.5mg | Upper step-up bridge dose (if needed) |
| Weeks 21+ | 15mg | Maximum licensed weekly maintenance strength |
Do you have to increase every 4 weeks up to 15mg?
No. At the end of each 4-week pen, your prescriber evaluates three things: how well your appetite and food noise are controlled, your steady weight-loss pace, and whether any GI side effects have settled. While 15mg produced the highest average weight loss in 72-week trials, 5mg and 10mg are both official maintenance doses — and holding at the lowest dose that keeps you losing comfortably protects both tolerability and monthly cost.
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References
- U.S. Food and Drug Administration. Mounjaro (tirzepatide) prescribing information. 2026.
- Jastreboff AM, et al. Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1). N Engl J Med. 2022;387(3):205–16.
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