Description
AMBLE · RESEARCH PRODUCT INFORMATION
Product overview
LL-37 is a human cathelicidin-derived peptide studied in innate-immunity research. The supplier discusses antimicrobial activity, inflammatory signaling and tissue-response models. These investigations do not establish an antibiotic or therapeutic use for this research vial.
For scientific research and development only. Intended for in-vitro laboratory work, not human or animal administration. Not for use as a medicine, diagnostic product, medical device, food, supplement or cosmetic. No dosing, injection or treatment instructions are provided.
Product specifications
| Quantity | 5mg |
|---|---|
| Unit | 1 vial |
| Physical Appearance | White powder |
| Salt form | Acetate |
| Supplier reference purity (not lot verification) | ≥99% |
| Sequence | Leu-Leu-Gly-Asp-Phe-Phe-Arg-Lys-Ser-Lys-Glu- Lys-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile- Lys-Asp-Phe-Leu-Arg-Asn-Leu-Val-Pro-Arg-Thr-Glu-Ser |
| Source-reported molecular mass (units not stated) | 4493.34 |
| CAS NO. | 154947-66-7 |
| Source-listed laboratory solvents | Bacteriostatic water |
Product features
- Source-listed pack: 5mg 1 vial
- Source-listed presentation: White powder
These characteristics identify the supplier reference presentation. They are not independent testing or verification of the current Amble lot.
These are reference specifications reported on the corresponding Particle Peptides page, not independent analytical verification of an Amble lot. Confirm the received label, identity, formulation and batch documentation before laboratory use. Unlisted fields have not been invented.
Storage and handling
1. Research use and restrictions
For scientific research and development only. Intended for in-vitro laboratory work, not human or animal administration. Not for use as a medicine, diagnostic product, medical device, food, supplement or cosmetic. No dosing, injection or treatment instructions are provided.
Literature involving animals or clinical studies is background information only and does not authorize this product for those uses. Do not supply this material for human investigational use.
2. Peptides in transport
Follow the current product label and lot-specific transport documentation. A general supplier statement about transport stability is not a guarantee for every formulation, liquid, blend or Amble shipment. The source supplier lists shipping restrictions for: Canada, Croatia, Czech Republic, Iceland, Ireland, Luxemburg, Norway, Serbia, South Africa, Switzerland. This is the supplier’s published list, not a complete legal assessment or a replacement for Amble’s shipping policy.
3. Storage of lyophilized peptides
The supplier gives general guidance to protect lyophilized peptides from light and moisture. Storage temperature and expiry must follow the actual formulation and lot documentation. Do not treat a generic storage-duration table as validated shelf-life data for this Amble product.
4. Storage of reconstituted peptides
Solution stability depends on sequence, formulation, solvent and handling. Use product-specific stability documentation and laboratory procedures rather than assuming the same refrigerated life for all peptides. The supplier’s Ipamorelin stability discussion cannot be extrapolated to other products without supporting data.
5. Storage of peptide solutions
Avoid unnecessary freeze–thaw cycling and follow the documented conditions for the exact solution. This page does not establish a validated shelf life after preparation. The listed solvent information is a supplier reference, not a patient-use or injection protocol.
Overview of published research
The corresponding source page discusses the topics below. They describe areas of investigation, not proven customer benefits, treatment indications or evidence that this particular Amble batch has been tested.
- Innate-immune signaling
- Antimicrobial activity in research systems
- Inflammation and tissue-response models
Interpretation depends on the study design, experimental material and model. The presence of a publication in a supplier bibliography is not an independent verification of the supplier’s interpretation or a guarantee of safety or effectiveness. No clinical doses or administration protocols are reproduced here.
Quality and documentation
Source attribution: the specifications and bibliography below refer to Particle Peptides. Amble branding does not turn the supplier’s studies or documents into Amble batch certifications.
View the corresponding supplier product page
- Supplier safety data sheet (MSDS)
- Supplier COA/test document — not verification of the current Amble lot
Document links are retained as supplier references. Confirm lot matching, document authenticity and applicability before relying on them; this update does not independently verify those documents.
Bibliography listed by the supplier (19 entries)
Bibliographic entries are attributed to the source page. Individual citations have not all been independently validated; consult the original publications and distinguish primary studies from secondary reports.
- Antonín Pavelka, Lukáš Vacek, Adam Norek, Šárka Kobzová, Lubomír Janda, „Recombinant production of human antimicrobial peptide LL-37 and its secondary structure”, Volume 79, pages 263–273, (2024)
- J. M. Kahlenberg and M. J. Kaplan, “Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease,” J. Immunol. Baltim. Md 1950, vol. 191, no. 10, Nov. 2013.
- D. S. Alexandre-Ramos et al., “LL-37 treatment on human peripheral blood mononuclear cells modulates immune response and promotes regulatory T-cells generation,” Biomed. Pharmacother. Biomedecine Pharmacother., vol. 108, pp. 1584–1590, Dec. 2018.
- P. Y. Ong et al., “Endogenous antimicrobial peptides and skin infections in atopic dermatitis,” N. Engl. J. Med., vol. 347, no. 15, pp. 1151–1160, Oct. 2002.
- C. D. Ciornei, T. Sigurdardóttir, A. Schmidtchen, and M. Bodelsson, “Antimicrobial and chemoattractant activity, lipopolysaccharide neutralization, cytotoxicity, and inhibition by serum of analogs of human cathelicidin LL-37,” Antimicrob. Agents Chemother., vol. 49, no. 7, pp. 2845–2850, Jul. 2005.
- X. Chen et al., “Synergistic effect of antibacterial agents human β-defensins, cathelicidin LL-37 and lysozyme against Staphylococcus aureus and Escherichia coli,” J. Dermatol. Sci., vol. 40, no. 2, pp. 123–132, Nov. 2005.
- M. Golec, “Cathelicidin LL-37: LPS-neutralizing, pleiotropic peptide,” Ann. Agric. Environ. Med. AAEM, vol. 14, no. 1, pp. 1–4, 2007.
- R. Shaykhiev et al., “Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure,” Am. J. Physiol. Lung Cell. Mol. Physiol., vol. 789, no. 5, pp. L842-848, Nov. 2005.
- M. H. Hoffmann et al., “The cathelicidins LL-37 and rCRAMP are associated with pathogenic events of arthritis in humans and rats,” Ann. Rheum. Dis., vol. 72, no. 7, pp. 1239–1248, Jul. 2013.
- D. Kienhöfer et al., “No evidence of pathogenic involvement of cathelicidins in patient cohorts and mouse models of lupus and arthritis,” PloS One, vol. 9, no. 12, p. e115474, 2014.
- L. N. Y. Chow et al., “Human cathelicidin LL-37-derived peptide IG-19 confers protection in a murine model of collagen-induced arthritis,” Mol. Immunol., vol. 57, no. 2, pp. 86–92, Feb. 2014.
- K.-Y. G. Choi, S. Napper, and N. Mookherjee, “Human cathelicidin LL-37 and its derivative IG-19 regulate interleukin-32-induced inflammation,” Immunology, vol. 143, no. 1, pp. 68–80, Sep. 2014.
- W. Zhu et al., “Arthritis is associated with T-cell-induced upregulation of Toll-like receptor 3 on synovial fibroblasts,” Arthritis Res. Ther., vol. 13, no. 3, p. R103, Jun. 2011.
- K. L. Brown et al., “Host defense peptide LL-37 selectively reduces proinflammatory macrophage responses,” J. Immunol. Baltim. Md 1950, vol. 186, no. 9, pp. 5497–5505, May 2011.
- J.-M. Otte et al., “Effects of the cathelicidin LL-37 on intestinal epithelial barrier integrity,” Regul. Pept., vol. 156, no. 1–3, pp. 104–117, Aug. 2009.
- J.-M. Otte et al., “Human beta defensin 2 promotes intestinal wound healing in vitro,” J. Cell. Biochem., vol. 104, no. 6, pp. 2286–2297, Aug. 2008.
- X. Chen et al., “Roles and Mechanisms of Human Cathelicidin LL-37 in Cancer,” Cell. Physiol. Biochem. Int. J. Exp. Cell. Physiol. Biochem. Pharmacol., vol. 47, no. 3, pp. 1060–1073, 2018.
- Salvado M. Dolores, Di Gennaro Antonio, Lindbom Lennart, Agerberth Birgitta, and Haeggström Jesper Z., “Cathelicidin LL-37 Induces Angiogenesis via PGE2–EP3 Signaling in Endothelial Cells, In Vivo Inhibition by Aspirin,” Arterioscler. Thromb. Vasc. Biol., vol. 33, no. 8, pp. 1965–1972, Aug. 2013.
- D. Xhindoli, S. Pacor, M. Benincasa, M. Scocchi, R. Gennaro, and A. Tossi, “The human cathelicidin LL-37 — A pore-forming antibacterial peptide and host-cell modulator,” Biochim. Biophys. Acta BBA – Biomembr., vol. 1858, no. 3, pp. 546–566, Mar. 2016.
Product questions and answers
What is LL-37 5mg?
LL-37 is a human cathelicidin-derived peptide studied in innate-immunity research. The supplier discusses antimicrobial activity, inflammatory signaling and tissue-response models. These investigations do not establish an antibiotic or therapeutic use for this research vial.
What quantity is listed for LL-37 5mg?
The corresponding supplier reference lists 5mg 1 vial. This applies to the stated presentation only; other strengths and quantities are not included.
Which identity or formulation details matter for LL-37 5mg?
The supplier provides 9 reference specification fields for this listing. Those fields and source documents are not an independent Amble batch certificate.
Does the linked documentation certify this Amble batch?
No Amble-lot certification is established by a supplier webpage or an unmatched COA. Confirm the laboratory report, exact batch number, identity and formulation before relying on the documentation.
What storage conditions are verified for LL-37 5mg?
Follow the actual lot label and product-specific safety and stability documentation. Generic storage tables and studies on another peptide do not establish this product’s shelf life.
Is LL-37 5mg intended for human use?
No. This is a research-use listing for in-vitro laboratory work, not human or animal administration. The page provides no dosing, injection or treatment instructions.
US online ordering information
Information for customers reviewing LL-37 5mg online from the United States.
This is a research-use listing, not a patient treatment or a finished medicine. Do not use it for human or animal administration. Review the exact formulation and lot-matched documentation, and confirm jurisdiction-specific eligibility before placing any order.
Use the live price and stock display on this page and review the final checkout total. Delivery, tax and return conditions depend on the product and destination; do not assume a delivery date or eligibility from this page alone.
For product or ordering questions, email hello@joinamblehealth.com. Read the Amble terms of service or visit your Amble account.
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